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Silencing of neurotropic flavivirus replication in the central nervous system by combining multiple microRNA target insertions in two distinct viral genome regions

In recent years, microRNA-targeting has become an effective strategy for selective control of tissue-tropism and pathogenesis of both DNA and RNA viruses. Here, using a neurotropic flavivirus as a model, we demonstrate that simultaneous miRNA targeting of the viral genome in the open reading frame a...

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Detalhes bibliográficos
Main Authors: Teterina, Natalya L., Liu, Guangping, Maximova, Olga A., Pletnev, Alexander G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4075184/
https://ncbi.nlm.nih.gov/pubmed/24889244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2014.04.001
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