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Insertion of MicroRNA Targets into the Flavivirus Genome Alters Its Highly Neurovirulent Phenotype

Flaviviruses such as West Nile, Japanese encephalitis, and tick-borne encephalitis (TBEV) viruses are important neurotropic human pathogens, causing a devastating and often fatal neuroinfection. Here, we demonstrate that incorporation into the viral genome of a target sequence for cellular microRNAs...

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Hlavní autoři: Heiss, Brian L., Maximova, Olga A., Pletnev, Alexander G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028900/
https://ncbi.nlm.nih.gov/pubmed/21123372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02091-10
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