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Insertion of MicroRNA Targets into the Flavivirus Genome Alters Its Highly Neurovirulent Phenotype

Flaviviruses such as West Nile, Japanese encephalitis, and tick-borne encephalitis (TBEV) viruses are important neurotropic human pathogens, causing a devastating and often fatal neuroinfection. Here, we demonstrate that incorporation into the viral genome of a target sequence for cellular microRNAs...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Heiss, Brian L., Maximova, Olga A., Pletnev, Alexander G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028900/
https://ncbi.nlm.nih.gov/pubmed/21123372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02091-10
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