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MicroRNA Targeting of Neurotropic Flavivirus: Effective Control of Virus Escape and Reversion to Neurovirulent Phenotype

Neurotropic flaviviruses can efficiently replicate in the developing and mature central nervous systems (CNS) of mice causing lethal encephalitis. Insertion of a single copy of a target for brain-expressed microRNAs (miRNAs) in the 3′ noncoding region (3′NCR) of the flavivirus genome (chimeric tick-...

詳細記述

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書誌詳細
主要な著者: Heiss, Brian L., Maximova, Olga A., Thach, Dzung C., Speicher, James M., Pletnev, Alexander G.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347253/
https://ncbi.nlm.nih.gov/pubmed/22419812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.07125-11
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