MicroRNA Targeting of Neurotropic Flavivirus: Effective Control of Virus Escape and Reversion to Neurovirulent Phenotype

Neurotropic flaviviruses can efficiently replicate in the developing and mature central nervous systems (CNS) of mice causing lethal encephalitis. Insertion of a single copy of a target for brain-expressed microRNAs (miRNAs) in the 3′ noncoding region (3′NCR) of the flavivirus genome (chimeric tick-...

Full description

Saved in:
Bibliographic Details
Main Authors: Heiss, Brian L., Maximova, Olga A., Thach, Dzung C., Speicher, James M., Pletnev, Alexander G.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347253/
https://ncbi.nlm.nih.gov/pubmed/22419812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.07125-11
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items