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MicroRNA Targeting of Neurotropic Flavivirus: Effective Control of Virus Escape and Reversion to Neurovirulent Phenotype

Neurotropic flaviviruses can efficiently replicate in the developing and mature central nervous systems (CNS) of mice causing lethal encephalitis. Insertion of a single copy of a target for brain-expressed microRNAs (miRNAs) in the 3′ noncoding region (3′NCR) of the flavivirus genome (chimeric tick-...

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Autori principali: Heiss, Brian L., Maximova, Olga A., Thach, Dzung C., Speicher, James M., Pletnev, Alexander G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347253/
https://ncbi.nlm.nih.gov/pubmed/22419812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.07125-11
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