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MicroRNA Targeting of Neurotropic Flavivirus: Effective Control of Virus Escape and Reversion to Neurovirulent Phenotype

Neurotropic flaviviruses can efficiently replicate in the developing and mature central nervous systems (CNS) of mice causing lethal encephalitis. Insertion of a single copy of a target for brain-expressed microRNAs (miRNAs) in the 3′ noncoding region (3′NCR) of the flavivirus genome (chimeric tick-...

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Bibliografski detalji
Glavni autori: Heiss, Brian L., Maximova, Olga A., Thach, Dzung C., Speicher, James M., Pletnev, Alexander G.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347253/
https://ncbi.nlm.nih.gov/pubmed/22419812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.07125-11
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