Comparative Neuropathogenesis and Neurovirulence of Attenuated Flaviviruses in Nonhuman Primates

Based on previous preclinical evaluation in mice and monkeys, the chimeric TBEV/DEN4Δ30 virus, carrying the prM and E protein genes from a highly virulent Far Eastern strain of tick-borne encephalitis virus (TBEV) on the backbone of a nonneuroinvasive dengue type 4 virus (DEN4), has been identified...

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Bibliographische Detailangaben
Hauptverfasser: Maximova, Olga A., Ward, Jerrold M., Asher, David M., St. Claire, Marisa, Finneyfrock, Brad W., Speicher, James M., Murphy, Brian R., Pletnev, Alexander G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2008
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2395187/
https://ncbi.nlm.nih.gov/pubmed/18353947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00172-08
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