Specificity of the dRP/AP Lyase of Ku Promotes Nonhomologous End Joining (NHEJ) Fidelity at Damaged Ends

Nonhomologous end joining (NHEJ) is essential for efficient repair of chromosome breaks. However, the NHEJ ligation step is often obstructed by break-associated nucleotide damage, including base loss (abasic site or 5′-dRP/AP sites). Ku, a 5′-dRP/AP lyase, can excise such damage at ends in preparati...

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Bibliographic Details
Main Authors: Strande, Natasha, Roberts, Steven A., Oh, Sehyun, Hendrickson, Eric A., Ramsden, Dale A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
DNA and Chromosomes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340204/
https://ncbi.nlm.nih.gov/pubmed/22362780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.329730
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