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Ku is a 5'dRP/AP lyase that excises nucleotide damage near broken ends
Mammalian cells require Nonhomologous end joining (NHEJ) for efficient repair of chromosomal DNA double-strand breaks1. A key feature of biological sources of strand breaks is associated nucleotide damage, including base loss (abasic or AP sites)2. At single strand breaks, 5' terminal abasic si...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2859099/ https://ncbi.nlm.nih.gov/pubmed/20383123 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08926 |
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