Ku is a 5'dRP/AP lyase that excises nucleotide damage near broken ends

Mammalian cells require Nonhomologous end joining (NHEJ) for efficient repair of chromosomal DNA double-strand breaks1. A key feature of biological sources of strand breaks is associated nucleotide damage, including base loss (abasic or AP sites)2. At single strand breaks, 5' terminal abasic si...

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Hlavní autoři: Roberts, Steven A., Strande, Natasha, Burkhalter, Martin D., Strom, Christina, Havener, Jody M., Hasty, Paul, Ramsden, Dale A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859099/
https://ncbi.nlm.nih.gov/pubmed/20383123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08926
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