Specificity of the dRP/AP Lyase of Ku Promotes Nonhomologous End Joining (NHEJ) Fidelity at Damaged Ends

Nonhomologous end joining (NHEJ) is essential for efficient repair of chromosome breaks. However, the NHEJ ligation step is often obstructed by break-associated nucleotide damage, including base loss (abasic site or 5′-dRP/AP sites). Ku, a 5′-dRP/AP lyase, can excise such damage at ends in preparati...

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Autors principals: Strande, Natasha, Roberts, Steven A., Oh, Sehyun, Hendrickson, Eric A., Ramsden, Dale A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
DNA and Chromosomes
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340204/
https://ncbi.nlm.nih.gov/pubmed/22362780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.329730
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