Specificity of the dRP/AP Lyase of Ku Promotes Nonhomologous End Joining (NHEJ) Fidelity at Damaged Ends

Nonhomologous end joining (NHEJ) is essential for efficient repair of chromosome breaks. However, the NHEJ ligation step is often obstructed by break-associated nucleotide damage, including base loss (abasic site or 5′-dRP/AP sites). Ku, a 5′-dRP/AP lyase, can excise such damage at ends in preparati...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Strande, Natasha, Roberts, Steven A., Oh, Sehyun, Hendrickson, Eric A., Ramsden, Dale A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2012
Gaiak:
DNA and Chromosomes
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340204/
https://ncbi.nlm.nih.gov/pubmed/22362780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.329730
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