Specificity of the dRP/AP Lyase of Ku Promotes Nonhomologous End Joining (NHEJ) Fidelity at Damaged Ends

Nonhomologous end joining (NHEJ) is essential for efficient repair of chromosome breaks. However, the NHEJ ligation step is often obstructed by break-associated nucleotide damage, including base loss (abasic site or 5′-dRP/AP sites). Ku, a 5′-dRP/AP lyase, can excise such damage at ends in preparati...

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Bibliografiske detaljer
Main Authors: Strande, Natasha, Roberts, Steven A., Oh, Sehyun, Hendrickson, Eric A., Ramsden, Dale A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
DNA and Chromosomes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340204/
https://ncbi.nlm.nih.gov/pubmed/22362780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.329730
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