Direct Evidence of Generation and Accumulation of β-Sheet-rich Prion Protein in Scrapie-infected Neuroblastoma Cells with Human IgG1 Antibody Specific for β-Form Prion Protein

We prepared β-sheet-rich recombinant full-length prion protein (β-form PrP) (Jackson, G. S., Hosszu, L. L., Power, A., Hill, A. F., Kenney, J., Saibil, H., Craven, C. J., Waltho, J. P., Clarke, A. R., and Collinge, J. (1999) Science 283, 1935–1937). Using this β-form PrP and a human single chain Fv-...

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Bibliographische Detailangaben
Hauptverfasser: Kubota, Toshiya, Hamazoe, Yuta, Hashiguchi, Shuhei, Ishibashi, Daisuke, Akasaka, Kazuyuki, Nishida, Noriyuki, Katamine, Shigeru, Sakaguchi, Suehiro, Kuroki, Ryota, Nakashima, Toshihiro, Sugimura, Kazuhisa
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Neurobiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340157/
https://ncbi.nlm.nih.gov/pubmed/22356913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.318352
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