Direct Evidence of Generation and Accumulation of β-Sheet-rich Prion Protein in Scrapie-infected Neuroblastoma Cells with Human IgG1 Antibody Specific for β-Form Prion Protein

We prepared β-sheet-rich recombinant full-length prion protein (β-form PrP) (Jackson, G. S., Hosszu, L. L., Power, A., Hill, A. F., Kenney, J., Saibil, H., Craven, C. J., Waltho, J. P., Clarke, A. R., and Collinge, J. (1999) Science 283, 1935–1937). Using this β-form PrP and a human single chain Fv-...

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Detalhes bibliográficos
Main Authors: Kubota, Toshiya, Hamazoe, Yuta, Hashiguchi, Shuhei, Ishibashi, Daisuke, Akasaka, Kazuyuki, Nishida, Noriyuki, Katamine, Shigeru, Sakaguchi, Suehiro, Kuroki, Ryota, Nakashima, Toshihiro, Sugimura, Kazuhisa
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340157/
https://ncbi.nlm.nih.gov/pubmed/22356913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.318352
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