Direct Evidence of Generation and Accumulation of β-Sheet-rich Prion Protein in Scrapie-infected Neuroblastoma Cells with Human IgG1 Antibody Specific for β-Form Prion Protein

We prepared β-sheet-rich recombinant full-length prion protein (β-form PrP) (Jackson, G. S., Hosszu, L. L., Power, A., Hill, A. F., Kenney, J., Saibil, H., Craven, C. J., Waltho, J. P., Clarke, A. R., and Collinge, J. (1999) Science 283, 1935–1937). Using this β-form PrP and a human single chain Fv-...

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Hlavní autoři: Kubota, Toshiya, Hamazoe, Yuta, Hashiguchi, Shuhei, Ishibashi, Daisuke, Akasaka, Kazuyuki, Nishida, Noriyuki, Katamine, Shigeru, Sakaguchi, Suehiro, Kuroki, Ryota, Nakashima, Toshihiro, Sugimura, Kazuhisa
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Neurobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340157/
https://ncbi.nlm.nih.gov/pubmed/22356913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.318352
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