Pressure-assisted dissociation and degradation of “proteinase K-resistant” fibrils prepared by seeding with scrapie-infected hamster prion protein

The crucial step for the fatal neurodegenerative prion diseases involves the conversion of a normal cellular protein, PrP(C), into a fibrous pathogenic form, PrP(Sc), which has an unusual stability against heat and resistance against proteinase K digestion. A successful challenge to reverse the reac...

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Dettagli Bibliografici
Pubblicato in:Prion
Autori principali: Akasaka, Kazuyuki, Maeno, Akihiro, Murayama, Taichi, Tachibana, Hideki, Fujita, Yuzo, Yamanaka, Hitoki, Nishida, Noriyuki, Atarashi, Ryuichiro
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2014
Soggetti:
Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601478/
https://ncbi.nlm.nih.gov/pubmed/25482603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.32081
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