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Loss of c-Met Accelerates Development of Liver Fibrosis in Response to CCl(4) Exposure through Deregulation of Multiple Molecular Pathways
HGF/c-Met signaling plays a pivotal role in hepatocyte survival and tissue remodeling during liver regeneration. HGF treatment accelerates resolution of fibrosis in experimental animal models. Here, we utilized Met(fl/fl);Alb-Cre(+/−) conditional knockout mice and a carbon tetrachloride(CCl(4))-indu...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3338880/ https://ncbi.nlm.nih.gov/pubmed/22386877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2012.02.012 |
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