Loss of c-Met Accelerates Development of Liver Fibrosis in Response to CCl(4) Exposure through Deregulation of Multiple Molecular Pathways

HGF/c-Met signaling plays a pivotal role in hepatocyte survival and tissue remodeling during liver regeneration. HGF treatment accelerates resolution of fibrosis in experimental animal models. Here, we utilized Met(fl/fl);Alb-Cre(+/−) conditional knockout mice and a carbon tetrachloride(CCl(4))-indu...

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Bibliografiska uppgifter
Huvudupphovsmän: Marquardt, Jens U, Seo, Daekwan, Gomez-Quiroz, Luis E, Uchida, Koichi, Gillen, Matthew C, Kitade, Mitsuteru, Kaposi-Novak, Pal, Conner, Elizabeth A, Factor, Valentina M, Thorgeirsson, Snorri S
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338880/
https://ncbi.nlm.nih.gov/pubmed/22386877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2012.02.012
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