A DNA hypermethylation module for the stem/progenitor cell signature of cancer

Many DNA-hypermethylated cancer genes are occupied by the Polycomb (PcG) repressor complex in embryonic stem cells (ESCs). Their prevalence in the full spectrum of cancers, the exact context of chromatin involved, and their status in adult cell renewal systems are unknown. Using a genome-wide analys...

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Hauptverfasser: Easwaran, Hariharan, Johnstone, Sarah E., Van Neste, Leander, Ohm, Joyce, Mosbruger, Tim, Wang, Qiuju, Aryee, Martin J., Joyce, Patrick, Ahuja, Nita, Weisenberger, Dan, Collisson, Eric, Zhu, Jingchun, Yegnasubramanian, Srinivasan, Matsui, William, Baylin, Stephen B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2012
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3337430/
https://ncbi.nlm.nih.gov/pubmed/22391556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.131169.111
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