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Stem cell chromatin patterns -- an instructive mechanism for DNA hypermethylation?

Epigenetic gene silencing, and associated promoter CpG island DNA hypermethylation, is an alternative mechanism to mutations by which tumor suppressor genes may be inactivated within a cancer cell 1-4,5-7. These epigenetic changes are prevalent in all types of cancer, and their appearance may preced...

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Detalhes bibliográficos
Main Authors: Ohm, Joyce E., Baylin, Stephen B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2707146/
https://ncbi.nlm.nih.gov/pubmed/17457052
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