PcG Proteins, DNA Methylation, and Gene Repression by Chromatin Looping

Many DNA hypermethylated and epigenetically silenced genes in adult cancers are Polycomb group (PcG) marked in embryonic stem (ES) cells. We show that a large region upstream (∼30 kb) of and extending ∼60 kb around one such gene, GATA-4, is organized—in Tera-2 undifferentiated embryonic carcinoma (E...

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Detalhes bibliográficos
Main Authors: Tiwari, Vijay K, McGarvey, Kelly M, Licchesi, Julien D.F, Ohm, Joyce E, Herman, James G, Schübeler, Dirk, Baylin, Stephen B
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2592355/
https://ncbi.nlm.nih.gov/pubmed/19053175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0060306
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