PcG Proteins, DNA Methylation, and Gene Repression by Chromatin Looping

Many DNA hypermethylated and epigenetically silenced genes in adult cancers are Polycomb group (PcG) marked in embryonic stem (ES) cells. We show that a large region upstream (∼30 kb) of and extending ∼60 kb around one such gene, GATA-4, is organized—in Tera-2 undifferentiated embryonic carcinoma (E...

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Bibliografiske detaljer
Main Authors: Tiwari, Vijay K, McGarvey, Kelly M, Licchesi, Julien D.F, Ohm, Joyce E, Herman, James G, Schübeler, Dirk, Baylin, Stephen B
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2592355/
https://ncbi.nlm.nih.gov/pubmed/19053175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0060306
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