PcG Proteins, DNA Methylation, and Gene Repression by Chromatin Looping

Many DNA hypermethylated and epigenetically silenced genes in adult cancers are Polycomb group (PcG) marked in embryonic stem (ES) cells. We show that a large region upstream (∼30 kb) of and extending ∼60 kb around one such gene, GATA-4, is organized—in Tera-2 undifferentiated embryonic carcinoma (E...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Tiwari, Vijay K, McGarvey, Kelly M, Licchesi, Julien D.F, Ohm, Joyce E, Herman, James G, Schübeler, Dirk, Baylin, Stephen B
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2008
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2592355/
https://ncbi.nlm.nih.gov/pubmed/19053175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0060306
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi