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PcG Proteins, DNA Methylation, and Gene Repression by Chromatin Looping
Many DNA hypermethylated and epigenetically silenced genes in adult cancers are Polycomb group (PcG) marked in embryonic stem (ES) cells. We show that a large region upstream (∼30 kb) of and extending ∼60 kb around one such gene, GATA-4, is organized—in Tera-2 undifferentiated embryonic carcinoma (E...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2592355/ https://ncbi.nlm.nih.gov/pubmed/19053175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0060306 |
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