A Stem Cell-Like Chromatin Pattern May Predispose Tumor Suppressor Genes to DNA Hypermethylation and Silencing in Adult Cancers

Adult cancers may derive from stem or early progenitor cells1,2. Epigenetic modulation of gene expression is essential for normal function of these early cells, but is highly abnormal in cancers, which often exhibit aberrant promoter CpG island hypermethylation and transcriptional silencing of tumor...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Ohm, Joyce E., McGarvey, Kelly M., Yu, Xiaobing, Cheng, Linzhao, Schuebel, Kornel E., Cope, Leslie, Mohammad, Helai P., Chen, Wei, Daniel, Vincent C., Yu, Wayne, Berman, David M., Jenuwein, Thomas, Pruitt, Kevin, Sharkis, Saul J., Watkins, D. Neil, Herman, James G., Baylin, Stephen B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2744394/
https://ncbi.nlm.nih.gov/pubmed/17211412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng1972
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados