A Stem Cell-Like Chromatin Pattern May Predispose Tumor Suppressor Genes to DNA Hypermethylation and Silencing in Adult Cancers

Adult cancers may derive from stem or early progenitor cells1,2. Epigenetic modulation of gene expression is essential for normal function of these early cells, but is highly abnormal in cancers, which often exhibit aberrant promoter CpG island hypermethylation and transcriptional silencing of tumor...

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Bibliografiske detaljer
Main Authors: Ohm, Joyce E., McGarvey, Kelly M., Yu, Xiaobing, Cheng, Linzhao, Schuebel, Kornel E., Cope, Leslie, Mohammad, Helai P., Chen, Wei, Daniel, Vincent C., Yu, Wayne, Berman, David M., Jenuwein, Thomas, Pruitt, Kevin, Sharkis, Saul J., Watkins, D. Neil, Herman, James G., Baylin, Stephen B.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2744394/
https://ncbi.nlm.nih.gov/pubmed/17211412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng1972
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