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Short dsRNA Induces Transcriptional Gene Silencing in Human Cancer Cells in the Absence of DNA Methylation
Double stranded RNAs (dsRNA) molecules targeted to gene promoter regions can induce transcriptional gene silencing in a DNA cytosine methylation dependent manner in plants (RNA-dependent DNA methylation or RdDM).1-3 Whether a similar mechanism exists in mammalian systems is a vital and currently con...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2659476/ https://ncbi.nlm.nih.gov/pubmed/16025112 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng1611 |
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