Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses

We show that DNA methyltransferase inhibitors (DNMTis) upregulate immune signaling in cancer through the viral defense pathway. In ovarian cancer (OC), DNMTis trigger cytosolic sensing of double-stranded RNA (dsRNA) causing a Type I Interferon response and apoptosis. Knocking down dsRNA sensors TLR3...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell
Main Authors: Chiappinelli, Katherine B., Strissel, Pamela L., Desrichard, Alexis, Li, Huili, Henke, Christine, Akman, Benjamin, Hein, Alexander, Rote, Neal S., Cope, Leslie M., Snyder, Alexandra, Makarov, Vladimir, Buhu, Sadna, Slamon, Dennis J., Wolchok, Jedd D., Pardoll, Drew M., Beckmann, Matthias W., Zahnow, Cynthia A., Mergoub, Taha, Chan, Timothy A., Baylin, Stephen B., Strick, Reiner
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556003/
https://ncbi.nlm.nih.gov/pubmed/26317466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.07.011
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados