Unraveling the molecular pathways of DNA-methylation inhibitors: human endogenous retroviruses induce the innate immune response in tumors

Loss of DNA methylation can activate endogenous retroviral expression and dsRNA in cancer cells. This leads to induction of toll-like receptor signaling stimulating an antiviral interferon response. Recent findings provide a therapeutic rationale for combining DNA methylation inhibitors with blockag...

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Publicado no:Oncoimmunology
Main Authors: Strick, Reiner, Strissel, Pamela L., Baylin, Stephen B., Chiappinelli, Katherine B.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4910697/
https://ncbi.nlm.nih.gov/pubmed/27467919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1122160
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