Polycomb CBX7 Promotes Initiation of Heritable Repression of Genes Frequently Silenced with Cancer Specific DNA Hypermethylation

Epigenetic silencing of genes in association with aberrant promoter DNA hypermethylation has emerged as a significant mechanism in the development of human cancers. Such genes are also often targets of the Polycomb group repressive complexes in embryonic cells. The Polycomb repressive complex (PRC)...

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Huvudupphovsmän: Mohammad, Helai P., Cai, Yi, McGarvey, Kelly M., Easwaran, Hariharan, Van Neste, Leander, Ohm, Joyce E., O’Hagan, Heather M., Baylin, Stephen B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2779702/
https://ncbi.nlm.nih.gov/pubmed/19602592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-0065
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