Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1

Diseases caused by the apicomplexan protozoans Toxoplasma gondii and Cryptosporidium parvum are a major health concern. The life cycle of these parasites is regulated by a family of calcium-dependent protein kinases (CDPKs) that have no direct homologs in the human host. Fortuitously, CDPK1 from bot...

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Autori principali: Larson, Eric T., Ojo, Kayode K., Murphy, Ryan C., Johnson, Steven M., Zhang, Zhongsheng, Kim, Jessica E., Leibly, David J., Fox, Anna M. W., Reid, Molly C., Dale, Edward J., Perera, B. Gayani K., Kim, Jae, Hewitt, Stephen N., Hol, Wim G. J., Verlinde, Christophe L. M. J., Fan, Erkang, Van Voorhis, Wesley C., Maly, Dustin J., Merritt, Ethan A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336864/
https://ncbi.nlm.nih.gov/pubmed/22369268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201725v
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