Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1

Diseases caused by the apicomplexan protozoans Toxoplasma gondii and Cryptosporidium parvum are a major health concern. The life cycle of these parasites is regulated by a family of calcium-dependent protein kinases (CDPKs) that have no direct homologs in the human host. Fortuitously, CDPK1 from bot...

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Main Authors: Larson, Eric T., Ojo, Kayode K., Murphy, Ryan C., Johnson, Steven M., Zhang, Zhongsheng, Kim, Jessica E., Leibly, David J., Fox, Anna M. W., Reid, Molly C., Dale, Edward J., Perera, B. Gayani K., Kim, Jae, Hewitt, Stephen N., Hol, Wim G. J., Verlinde, Christophe L. M. J., Fan, Erkang, Van Voorhis, Wesley C., Maly, Dustin J., Merritt, Ethan A.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336864/
https://ncbi.nlm.nih.gov/pubmed/22369268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201725v
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