VUF10166, a Novel Compound with Differing Activities at 5-HT(3)A and 5-HT(3)AB Receptors

The actions of a novel, potent 5-HT(3) receptor ligand, [2-chloro-(4-methylpiperazine-1-yl)quinoxaline (VUF10166)], were examined at heterologously expressed human 5-HT(3)A and 5-HT(3)AB receptors. VUF10166 displaced [(3)H]granisetron binding to 5-HT(3)A receptors expressed in human embryonic kidney...

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Main Authors: Thompson, A. J., Verheij, M. H. P., de Esch, I. J. P., Lummis, S. C. R.
格式: Artigo
語言:Inglês
出版: The American Society for Pharmacology and Experimental Therapeutics 2012
主題:
Neuropharmacology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336813/
https://ncbi.nlm.nih.gov/pubmed/22306960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.190769
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