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Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity

We report the results of an in vitro screening assay targeting the intraerythrocytic form of the malaria parasite Plasmodium falciparum using a library of 560 prenyl-synthase inhibitors. Based on “growth-rescue” and enzyme-inhibition experiments, geranylgeranyl diphosphate synthase (GGPPS) is shown...

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書誌詳細
主要な著者: No, Joo Hwan, de Macedo Dossin, Fernando, Zhang, Yonghui, Liu, Yi-Liang, Zhu, Wei, Feng, Xinxin, Yoo, Jinyoung Anny, Lee, Eunhae, Wang, Ke, Hui, Raymond, Freitas-Junior, Lucio H., Oldfield, Eric
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2012
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オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306666/
https://ncbi.nlm.nih.gov/pubmed/22392982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118215109
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