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Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity
We report the results of an in vitro screening assay targeting the intraerythrocytic form of the malaria parasite Plasmodium falciparum using a library of 560 prenyl-synthase inhibitors. Based on “growth-rescue” and enzyme-inhibition experiments, geranylgeranyl diphosphate synthase (GGPPS) is shown...
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主要な著者: | , , , , , , , , , , , |
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フォーマット: | Artigo |
言語: | Inglês |
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National Academy of Sciences
2012
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3306666/ https://ncbi.nlm.nih.gov/pubmed/22392982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118215109 |
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