Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity

We report the results of an in vitro screening assay targeting the intraerythrocytic form of the malaria parasite Plasmodium falciparum using a library of 560 prenyl-synthase inhibitors. Based on “growth-rescue” and enzyme-inhibition experiments, geranylgeranyl diphosphate synthase (GGPPS) is shown...

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Bibliographic Details
Main Authors: No, Joo Hwan, de Macedo Dossin, Fernando, Zhang, Yonghui, Liu, Yi-Liang, Zhu, Wei, Feng, Xinxin, Yoo, Jinyoung Anny, Lee, Eunhae, Wang, Ke, Hui, Raymond, Freitas-Junior, Lucio H., Oldfield, Eric
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Physical Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306666/
https://ncbi.nlm.nih.gov/pubmed/22392982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118215109
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