Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity

We report the results of an in vitro screening assay targeting the intraerythrocytic form of the malaria parasite Plasmodium falciparum using a library of 560 prenyl-synthase inhibitors. Based on “growth-rescue” and enzyme-inhibition experiments, geranylgeranyl diphosphate synthase (GGPPS) is shown...

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Autores principales: No, Joo Hwan, de Macedo Dossin, Fernando, Zhang, Yonghui, Liu, Yi-Liang, Zhu, Wei, Feng, Xinxin, Yoo, Jinyoung Anny, Lee, Eunhae, Wang, Ke, Hui, Raymond, Freitas-Junior, Lucio H., Oldfield, Eric
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2012
Materias:
Physical Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306666/
https://ncbi.nlm.nih.gov/pubmed/22392982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118215109
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