G protein-coupled receptor inactivation by an allosteric inverse-agonist antibody

G protein-coupled receptors (GPCRs) are the largest class of cell-surface receptors, and these membrane proteins exist in equilibrium between inactive and active states.(1-13) Conformational changes induced by extracellular ligands binding to GPCRs result in a cellular response through the activatio...

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Bibliografiske detaljer
Main Authors: Hino, Tomoya, Arakawa, Takatoshi, Iwanari, Hiroko, Yurugi-Kobayashi, Takami, Ikeda-Suno, Chiyo, Nakada-Nakura, Yoshiko, Kusano-Arai, Osamu, Weyand, Simone, Shimamura, Tatsuro, Nomura, Norimichi, Cameron, Alexander D., Kobayashi, Takuya, Hamakubo, Takao, Iwata, So, Murata, Takeshi
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3303121/
https://ncbi.nlm.nih.gov/pubmed/22286059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10750
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