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High-resolution crystal structure of the therapeutic antibody pembrolizumab bound to the human PD-1

Pembrolizumab is an FDA-approved therapeutic antibody that targets the programmed cell death-1 (PD-1) to block the immune checkpoint pathway for the treatment of various types of cancer. It receives remarkable attention due to the high degree of efficacy. Very recently, the crystal structure of the...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Horita, Shoichiro, Nomura, Yayoi, Sato, Yumi, Shimamura, Tatsuro, Iwata, So, Nomura, Norimichi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5062252/
https://ncbi.nlm.nih.gov/pubmed/27734966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35297
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