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High-resolution crystal structure of the therapeutic antibody pembrolizumab bound to the human PD-1

Pembrolizumab is an FDA-approved therapeutic antibody that targets the programmed cell death-1 (PD-1) to block the immune checkpoint pathway for the treatment of various types of cancer. It receives remarkable attention due to the high degree of efficacy. Very recently, the crystal structure of the...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Horita, Shoichiro, Nomura, Yayoi, Sato, Yumi, Shimamura, Tatsuro, Iwata, So, Nomura, Norimichi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2016
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5062252/
https://ncbi.nlm.nih.gov/pubmed/27734966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35297
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