Structure and mechanism of the mammalian fructose transporter GLUT5

The altered activity of the fructose transporter GLUT5, an isoform of the facilitated-diffusion glucose transporter family, has been linked to disorders such as type 2 diabetes and obesity. GLUT5 is also overexpressed in certain tumor cells and inhibitors are potential drugs for these conditions. He...

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Published in:Nature
Main Authors: Nomura, Norimichi, Verdon, Grégory, Kang, Hae Joo, Shimamura, Tatsuro, Nomura, Yayoi, Sonoda, Yo, Hussien, Saba Abdul, Qureshi, Aziz Abdul, Coincon, Mathieu, Sato, Yumi, Abe, Hitomi, Nakada-Nakura, Yoshiko, Hino, Tomoya, Arakawa, Takatoshi, Kusano-Arai, Osamu, Iwanari, Hiroko, Murata, Takeshi, Kobayashi, Takuya, Hamakubo, Takao, Kasahara, Michihiro, Iwata, So, Drew, David
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618315/
https://ncbi.nlm.nih.gov/pubmed/26416735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14909
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