Glycolytic inhibition causes spontaneous ventricular fibrillation in aged hearts

Selective glycolytic inhibition (GI) promotes electromechanical alternans and triggered beats in isolated cardiac myocytes. We sought to determine whether GI promotes triggered activity by early afterdepolarization (EAD) or delayed afterdepolarizations in intact hearts isolated from adult and aged r...

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Autores principales: Morita, Norishige, Lee, Jong-Hwan, Bapat, Aneesh, Fishbein, Michael C., Mandel, William J., Chen, Peng-Sheng, Weiss, James N., Karagueuzian, Hrayr S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2011
Materias:
Cardiac Excitation and Contraction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302192/
https://ncbi.nlm.nih.gov/pubmed/21478408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00128.2011
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