Glycolytic inhibition causes spontaneous ventricular fibrillation in aged hearts

Selective glycolytic inhibition (GI) promotes electromechanical alternans and triggered beats in isolated cardiac myocytes. We sought to determine whether GI promotes triggered activity by early afterdepolarization (EAD) or delayed afterdepolarizations in intact hearts isolated from adult and aged r...

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Main Authors: Morita, Norishige, Lee, Jong-Hwan, Bapat, Aneesh, Fishbein, Michael C., Mandel, William J., Chen, Peng-Sheng, Weiss, James N., Karagueuzian, Hrayr S.
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2011
Assuntos:
Cardiac Excitation and Contraction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302192/
https://ncbi.nlm.nih.gov/pubmed/21478408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00128.2011
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