Enhanced sensitivity of aged fibrotic hearts to angiotensin II- and hypokalemia-induced early afterdepolarization-mediated ventricular arrhythmias

Unlike young hearts, aged hearts are highly susceptible to early afterdepolarization (EAD)-mediated ventricular fibrillation (VF). This differential may result from age-related structural remodeling (fibrosis) or electrical remodeling of ventricular myocytes or both. We used optical mapping and micr...

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Detalhes bibliográficos
Main Authors: Bapat, Aneesh, Nguyen, Thao P., Lee, Jong-Hwan, Sovari, Ali A., Fishbein, Michael C., Weiss, James N., Karagueuzian, Hrayr S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
Assuntos:
Integrative Cardiovascular Physiology and Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378307/
https://ncbi.nlm.nih.gov/pubmed/22467308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00094.2012
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