Φορτώνει......
Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCF(Cdc4) ubiquitin ligase
The ubiquitin ligase SCF(Cdc4) (Skp1/Cul1/F-box protein) recognizes its substrate, the cyclin-dependent kinase inhibitor Sic1, in a multisite phosphorylation-dependent manner. Although short diphosphorylated peptides derived from Sic1 can bind to Cdc4 with high affinity, through systematic mutagenes...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
National Academy of Sciences
2012
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3295303/ https://ncbi.nlm.nih.gov/pubmed/22328159 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1116455109 |
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