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Probing chelation motifs in HIV integrase inhibitors
A series of HIV integrase (HIV-1 IN) inhibitors were synthesized to evaluate the role of the metal-binding group (MBG) in this class of metalloenzyme inhibitors. A total of 21 different raltegravir-chelator derivative (RCD) compounds were prepared that differed only in the nature of the MBG. These I...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3289312/ https://ncbi.nlm.nih.gov/pubmed/22308350 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112389109 |
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