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3-Hydroxypyrimidine-2,4-diones as an Inhibitor Scaffold of HIV Integrase

Integrase (IN) represents a clinically validated target for the development of antivirals against human immunodeficiency virus (HIV). Inhibitors with a novel structure core are essential for combating resistance associated with known IN inhibitors (INIs). We have previously disclosed a novel dual in...

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Detalhes bibliográficos
Main Authors: Tang, Jing, Maddali, Kasthuraiah, Sham, Yuk Y., Vince, Robert, Pommier, Yves, Wang, Zhengqiang
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072462/
https://ncbi.nlm.nih.gov/pubmed/21381765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1014378
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