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Scaffold rearrangement of dihydroxypyrimidine inhibitors of HIV integrase: Docking model revisited
A series of dihydroxypyrimidine (DHP) derivatives were designed as inhibitors of HIV integrase (IN) based on known homology models. Through chemical synthesis and biochemical assays it was found that the activity profile of these compounds largely deviates from predictions with existing models. With...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7323870/ https://ncbi.nlm.nih.gov/pubmed/20457521 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.04.048 |
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