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Diketoacid – Genre HIV-1 Integrase Inhibitors Containing Enantiomeric Arylamide Functionality
Using our recently disclosed 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-one and 4,5-dihydroxy-1H-isoindole-1,3(2H)-dione integrase inhibitors, we report differential effects on inhibitory potency induced by introduction of an α-chiral center into a key aryl substitutent. We show that introduction of th...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2747503/ https://ncbi.nlm.nih.gov/pubmed/19527935 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.05.008 |
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