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Diketoacid – Genre HIV-1 Integrase Inhibitors Containing Enantiomeric Arylamide Functionality

Using our recently disclosed 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-one and 4,5-dihydroxy-1H-isoindole-1,3(2H)-dione integrase inhibitors, we report differential effects on inhibitory potency induced by introduction of an α-chiral center into a key aryl substitutent. We show that introduction of th...

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Detalhes bibliográficos
Main Authors: Zhao, Xue Zhi, Maddali, Kasthuraiah, Marchand, Christophe, Pommier, Yves, Burke, Terrence R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747503/
https://ncbi.nlm.nih.gov/pubmed/19527935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.05.008
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