Development of Tricyclic Hydroxy-1H-pyrrolopyridine-trione Containing HIV-1 Integrase Inhibitors

New tricyclic HIV-1 integrase (IN) inhibitors were prepared that combined structural features of bicyclic pyrimidinones with recently disclosed 4,5-dihydroxy-1H-isoindole-1,3(2H)-diones. This combination resulted in the introduction of a nitrogen into the aryl ring and the addition of a fused third...

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Detalhes bibliográficos
Main Authors: Zhao, Xue Zhi, Maddali, Kasthuraiah, Metifiot, Mathieu, Smith, Steven J., Vu, B. Christie, Marchand, Christophe, Hughes, Stephen H., Pommier, Yves, Burke, Terrence R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085635/
https://ncbi.nlm.nih.gov/pubmed/21493066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.03.047
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