In Situ Genetic Correction of the Sickle Cell Anemia Mutation in Human Induced Pluripotent Stem Cells Using Engineered Zinc Finger Nucleases

The combination of induced pluripotent stem (iPS) cell technology and targeted gene modification by homologous recombination (HR) represents a promising new approach to generate genetically corrected, patient-derived cells that could be used for autologous transplantation therapies. This strategy ha...

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Detalles Bibliográficos
Autores principales: Sebastiano, Vittorio, Maeder, Morgan L., Angstman, James F., Haddad, Bahareh, Khayter, Cyd, Yeo, Dana T., Goodwin, Mathew J., Hawkins, John S., Ramirez, Cherie L., Batista, Luis F.Z., Artandi, Steven E., Wernig, Marius, Joung, J. Keith
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285772/
https://ncbi.nlm.nih.gov/pubmed/21898685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.718
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