In Situ Genetic Correction of the Sickle Cell Anemia Mutation in Human Induced Pluripotent Stem Cells Using Engineered Zinc Finger Nucleases

The combination of induced pluripotent stem (iPS) cell technology and targeted gene modification by homologous recombination (HR) represents a promising new approach to generate genetically corrected, patient-derived cells that could be used for autologous transplantation therapies. This strategy ha...

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Bibliografiske detaljer
Main Authors: Sebastiano, Vittorio, Maeder, Morgan L., Angstman, James F., Haddad, Bahareh, Khayter, Cyd, Yeo, Dana T., Goodwin, Mathew J., Hawkins, John S., Ramirez, Cherie L., Batista, Luis F.Z., Artandi, Steven E., Wernig, Marius, Joung, J. Keith
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285772/
https://ncbi.nlm.nih.gov/pubmed/21898685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.718
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