In Situ Genetic Correction of the Sickle Cell Anemia Mutation in Human Induced Pluripotent Stem Cells Using Engineered Zinc Finger Nucleases

The combination of induced pluripotent stem (iPS) cell technology and targeted gene modification by homologous recombination (HR) represents a promising new approach to generate genetically corrected, patient-derived cells that could be used for autologous transplantation therapies. This strategy ha...

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Detalhes bibliográficos
Main Authors: Sebastiano, Vittorio, Maeder, Morgan L., Angstman, James F., Haddad, Bahareh, Khayter, Cyd, Yeo, Dana T., Goodwin, Mathew J., Hawkins, John S., Ramirez, Cherie L., Batista, Luis F.Z., Artandi, Steven E., Wernig, Marius, Joung, J. Keith
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285772/
https://ncbi.nlm.nih.gov/pubmed/21898685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.718
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