Evaluation of OPEN Zinc Finger Nucleases for Direct Gene Targeting of the ROSA26 Locus in Mouse Embryos

Zinc finger nucleases (ZFNs) enable precise genome modification in a variety of organisms and cell types. Commercial ZFNs were reported to enhance gene targeting directly in mouse zygotes, whereas similar approaches using publicly available resources have not yet been described. Here we report preci...

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Bibliografski detalji
Glavni autori: Hermann, Mario, Maeder, Morgan L., Rector, Kyle, Ruiz, Joseph, Becher, Burkhard, Bürki, Kurt, Khayter, Cyd, Aguzzi, Adriano, Joung, J. Keith, Buch, Thorsten, Pelczar, Pawel
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3435328/
https://ncbi.nlm.nih.gov/pubmed/22970113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041796
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