Evaluation of OPEN Zinc Finger Nucleases for Direct Gene Targeting of the ROSA26 Locus in Mouse Embryos

Zinc finger nucleases (ZFNs) enable precise genome modification in a variety of organisms and cell types. Commercial ZFNs were reported to enhance gene targeting directly in mouse zygotes, whereas similar approaches using publicly available resources have not yet been described. Here we report preci...

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Autors principals: Hermann, Mario, Maeder, Morgan L., Rector, Kyle, Ruiz, Joseph, Becher, Burkhard, Bürki, Kurt, Khayter, Cyd, Aguzzi, Adriano, Joung, J. Keith, Buch, Thorsten, Pelczar, Pawel
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3435328/
https://ncbi.nlm.nih.gov/pubmed/22970113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041796
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