Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib

BCR-ABL tyrosine kinase inhibitors (TKI) fail to eliminate quiescent leukemia stem cells (LSC) in chronic myelogenous leukemia (CML). Thus strategies targeting LSC are required to achieve cure. We show that the NAD(+) dependent deacetylase SIRT1 is overexpressed in human CML LSC. Pharmacological inh...

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Detalhes bibliográficos
Main Authors: Li, Ling, Wang, Lisheng, Li, Liang, Wang, Zhiqiang, Ho, Yinwei, McDonald, Tinisha, Holyoake, Tessa L., Chen, WenYong, Bhatia, Ravi
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285436/
https://ncbi.nlm.nih.gov/pubmed/22340598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.12.020
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